Computational Biology
@ Comenius University in Bratislava

Marmoset Genome Sequencing and Analysis Consortium. The common marmoset genome provides insight into primate biology and evolution. Nature Genetics, 46(8):850-857. 2014.

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Download from publisher: http://dx.doi.org/10.1038/ng.3042

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Abstract:

We report the whole-genome sequence of the common marmoset (Callithrix jacchus). 
The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6x)
and a whole-genome shotgun strategy. A first analysis has permitted comparison
with the genomes of apes and Old World monkeys and the identification of specific
features that might contribute to the unique biology of this diminutive primate, 
including genetic changes that may influence body size, frequent twinning and
chimerism. We observed positive selection in growth hormone/insulin-like growth
factor genes (growth pathways), respiratory complex I genes (metabolic pathways),
and genes encoding immunobiological factors and proteases (reproductive and
immunity pathways). In addition, both protein-coding and microRNA genes related
to reproduction exhibited evidence of rapid sequence evolution. This genome
sequence for a New World monkey enables increased power for comparative analyses 
among available primate genomes and facilitates biomedical research application.