Computational Biology
@ Comenius University in Bratislava

Cody J. Steely, Jasmine N. Baker, Jerilyn A. Walker, Charles D. 3rd Loupe, {Baboon Genome Analysis Consortium}, Mark A. Batzer. Analysis of lineage-specific Alu subfamilies in the genome of the olive baboon,Papio anubis. Mobile DNA, 9:10. 2018. Tomas Vinar is a member of the Baboon Genome Analysis Consortium.

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Download from publisher: https://doi.org/10.1186/s13100-018-0115-6

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Abstract:

Background: Alu elements are primate-specific retroposons that mobilize using the
enzymatic machinery of L1 s. The recently completed baboon genome project found
that the mobilization rate of Alu elements is higher than in the genome of any
other primate studied thus far. However, the Alu subfamily structure present in
and specific to baboons had not been examined yet. Results: Here we report 129
Alu subfamilies that are propagating in the genome of the olive baboon, with 127 
of these subfamilies being new and specific to the baboon lineage. We analyzed
233 Alu insertions in the genome of the olive baboon using locus specific
polymerase chain reaction assays, covering 113 of the 129 subfamilies. The allele
frequency data from these insertions show that none of the nine groups of
subfamilies are nearing fixation in the lineage. Conclusions: Many subfamilies of
Alu elements are actively mobilizing throughout the baboon lineage, with most
being specific to the baboon lineage.