Computational Biology
@ Comenius University in Bratislava

Bronislava Brejova, Hana Lichancova, Filip Brazdovic, Eva Hegedusova, Michaela {Forgacova Jakubkova}, Viktoria Hodorova, Vladimira Dzugasova, Andrej Balaz, Lucia Zeiselova, Andrea Cillingova, Martina Nebohacova, Vladislav Raclavsky, Lubomir Tomaska, B. Franz Lang, Tomas Vinar, Jozef Nosek. Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus. Current Genetics, 65(2):539-560. 2019.

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Download from publisher: https://doi.org/10.1007/s00294-018-0904-y

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Abstract:

The yeast Magnusiomyces capitatus is an opportunistic human pathogen causing rare
yet severe infections, especially in patients with hematological malignancies.
Here, we report the 20.2 megabase genome sequence of an environmental strain of
this species as well as the genome sequences of eight additional isolates from
human and animal sources providing an insight into intraspecies variation. The
distribution of single-nucleotide variants is indicative of genetic recombination
events, supporting evidence for sexual reproduction in this heterothallic yeast. 
Using RNAseq-aided annotation, we identified genes for 6518 proteins including
several expanded families such as kexin proteases and Hsp70 molecular chaperones.
Several of these families are potentially associated with the ability of M.
capitatus to infect and colonize humans. For the purpose of comparative analysis,
we also determined the genome sequence of a closely related yeast, Magnusiomyces 
ingens. The genome sequences of M. capitatus and M. ingens exhibit many distinct 
features and represent a basis for further comparative and functional studies.