Computational Biology
@ Comenius University in Bratislava

Filip Brazdovic, Brona Brejova, Barbara Sivakova, Peter Barath, Filip Kerak, Viktoria Hodorova, Tomas Vinar, Lubomir Tomaska, Jozef Nosek. Reduction of Ribosomal Expansion Segments in Yeast Species of the Magnusiomyces/Saprochaete Clade. Genome Biol Evol, 16(8). 2024.

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Download from publisher: https://doi.org/10.1093/gbe/evae173

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Abstract:

Ribosomes are ribonucleoprotein complexes highly conserved across all domains of 
life. The size differences of ribosomal RNAs (rRNAs) can be mainly attributed to 
variable regions termed expansion segments (ESs) protruding out from the 
ribosomal surface. The ESs were found to be involved in a range of processes 
including ribosome biogenesis and maturation, translation, and co-translational 
protein modification. Here, we analyze the rRNAs of the yeasts from the 
Magnusiomyces/Saprochaete clade belonging to the basal lineages of the subphylum 
Saccharomycotina. We find that these yeasts are missing more than 400 nt from the 
25S rRNA and 150 nt from the 18S rRNAs when compared to their canonical 
counterparts in Saccharomyces cerevisiae. The missing regions mostly map to ESs, 
thus representing a shift toward a minimal rRNA structure. Despite the structural 
changes in rRNAs, we did not identify dramatic alterations in the ribosomal 
protein inventories. We also show that the size-reduced rRNAs are not limited to 
the species of the Magnusiomyces/Saprochaete clade, indicating that the 
shortening of ESs happened independently in several other lineages of the 
subphylum Saccharomycotina.