Basic Information

NameHexaprenyl pyrophosphate synthase, mitochondrial (HPS) (EC 2.5.1.-)
Uniprot IDP18900
Systematic gene nameYBR003W
Standard gene nameCOQ1
Gene namesCOQ1 YBR003W YBR0109
Description from SGDYBR003W COQ1 SGDID:S000000207, Chr II from 242809-244230, Genome Release 64-3-1, Verified ORF, "Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis"
Protein length473
Downloadsequence (fasta, from Uniprot), modifications (csv format)
Database linksUniprot, SGD, TheCellVision.org, FungiDB

Sequence

MFQRSGAAHH IKLISSRRCR FKSSFAVALN AASKLVTPKI LWNNPISLVS
KEMNTLAKNI VALIGSGHPV LNKVTSYYFE TEGKKVRPLL VLLLSRALSE
IPMTERNHLK IDKSDVPEDP IYSKPSQNQL FQRPASSISP LHILHGIKPL
NPLTKGPEPL PEETFDKQRG ILPKQRRLAE IVEMIHTASL LHDDVIDHSD
TRRGRPSGNA AFTNKMAVLA GDFLLGRATV SISRLHNPEV VELMSNSIAN
LVEGEFMQLK NTSIDADIDT IENGHKLLPV PSKKLEVKEH DFRVPSRQQG
LQLSHDQIIE TAFEYYIHKT YLKTAALISK SCRCAAILSG ASPAVIDECY
DFGRNLGICF QLVDDMLDFT VSGKDLGKPS GADLKLGIAT APVLFAWKED
PSLGPLISRN FSERGDVEKT IDSVRLHNGI AKTKILAEEY RDKALQNLRD
SLPESDARSA LEFLTNSILT RRK

Legend

  • X Phoshorylation
  • X K-Succinylation

Structure

Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.


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References

[23, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[23, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[167, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)
[263, Phos]Vlastaridis P, Kyriakidou P, Chaliotis A, et al (2017) Estimating the total number of phosphoproteins and phosphorylation sites in eukaryotic proteomes. GigaScience 6:1–11. (Publication) (All modifications)
[263, Phos]Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[263, Phos]Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[434, K-succ]Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications)