Basic Information
Name | Mitochondrial import receptor subunit TOM40 (Mitochondrial import site protein ISP42) (Translocase of outer membrane 40 kDa subunit) |
Uniprot ID | P23644 |
Systematic gene name | YMR203W |
Standard gene name | TOM40 |
Gene names | TOM40 ISP42 MOM38 YMR203W YM8325.04 |
Description from SGD | YMR203W TOM40 SGDID:S000004816, Chr XIII from 668492-669655, Genome Release 64-3-1, Verified ORF, "Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions" |
Protein length | 387 |
Download | sequence (fasta, from Uniprot), modifications (csv format) |
Database links | Uniprot, SGD, TheCellVision.org, FungiDB |
Sequence
MSAPTPLAEA SQIPTIPALS PLTAKQSKGN FFSSNPISSF VVDTYKQLHS
HRQSLELVNP GTVENLNKEV SRDVFLSQYF FTGLRADLNK AFSMNPAFQT
SHTFSIGSQA LPKYAFSALF ANDNLFAQGN IDNDLSVSGR LNYGWDKKNI
SKVNLQISDG QPTMCQLEQD YQASDFSVNV KTLNPSFSEK GEFTGVAVAS
FLQSVTPQLA LGLETLYSRT DGSAPGDAGV SYLTRYVSKK QDWIFSGQLQ
ANGALIASLW RKVAQNVEAG IETTLQAGMV PITDPLMGTP IGIQPTVEGS
TTIGAKYEYR QSVYRGTLDS NGKVACFLER KVLPTLSVLF CGEIDHFKND
TKIGCGLQFE TAGNQELLML QQGLDADGNP LQALPQL
HRQSLELVNP GTVENLNKEV SRDVFLSQYF FTGLRADLNK AFSMNPAFQT
SHTFSIGSQA LPKYAFSALF ANDNLFAQGN IDNDLSVSGR LNYGWDKKNI
SKVNLQISDG QPTMCQLEQD YQASDFSVNV KTLNPSFSEK GEFTGVAVAS
FLQSVTPQLA LGLETLYSRT DGSAPGDAGV SYLTRYVSKK QDWIFSGQLQ
ANGALIASLW RKVAQNVEAG IETTLQAGMV PITDPLMGTP IGIQPTVEGS
TTIGAKYEYR QSVYRGTLDS NGKVACFLER KVLPTLSVLF CGEIDHFKND
TKIGCGLQFE TAGNQELLML QQGLDADGNP LQALPQL
Legend
- X Phoshorylation
- X Multiple modifications
Structure
Structure visualized by GLmol written by biochem_fan. The structure was downloaded from the AlphaFold Protein Structure Database.
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References
[2, Phos] | Schmidt O, Harbauer AB, Rao S, et al (2011) Regulation of mitochondrial protein import by cytosolic kinases. Cell 144:227–239. (Publication) (All modifications) |
[2, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |
[5, Phos] | Schmidt O, Harbauer AB, Rao S, et al (2011) Regulation of mitochondrial protein import by cytosolic kinases. Cell 144:227–239. (Publication) (All modifications) |
[5, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |
[11, Phos] | Schmidt O, Harbauer AB, Rao S, et al (2011) Regulation of mitochondrial protein import by cytosolic kinases. Cell 144:227–239. (Publication) (All modifications) |
[11, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |
[50, Phos] | Schmidt O, Harbauer AB, Rao S, et al (2011) Regulation of mitochondrial protein import by cytosolic kinases. Cell 144:227–239. (Publication) (All modifications) |
[50, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |
[54, Phos] | Schmidt O, Harbauer AB, Rao S, et al (2011) Regulation of mitochondrial protein import by cytosolic kinases. Cell 144:227–239. (Publication) (All modifications) |
[54, Phos] | Guo X, Niemi NM, Coon JJ, Pagliarini DJ (2017a) Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase. J Biol Chem 292:11751–11759. (Publication) (All modifications) |
[54, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |
[77, Phos] | Schmidt O, Harbauer AB, Rao S, et al (2011) Regulation of mitochondrial protein import by cytosolic kinases. Cell 144:227–239. (Publication) (All modifications) |
[77, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |
[147, K-succ] | Frankovsky, J., Keresztesová, B., Bellová, J., et al. (2021). The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. Journal of Biological Chemistry, 297(4): 101155. (Publication) (All modifications) |
[147, K-acetyl] | Henriksen, P., Wagner, S. A., Weinert, B. T., et al. (2012). Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Molecular & Cellular Proteomics, 11(11), 1510-1522. (Publication) (All modifications) |
[220, Phos] | Schmidt O, Harbauer AB, Rao S, et al (2011) Regulation of mitochondrial protein import by cytosolic kinases. Cell 144:227–239. (Publication) (All modifications) |
[220, Phos] | Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications) |