P40015

Name	Inositol phosphosphingolipids phospholipase C (IPS phospholipase C) (IPS-PLC) (EC 3.1.4.-) (Neutral sphingomyelinase) (N-SMase) (nSMase)
Uniprot ID	P40015
Systematic gene name	YER019W
Standard gene name	ISC1
Gene names	ISC1 YER019W
Description from SGD	YER019W ISC1 SGDID:S000000821, Chr V from 192797-194230, Genome Release 64-3-1, Verified ORF, "Inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; regulates the spindle assembly checkpoint upstream of PP2A-Cdc55; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; mediates Na+ and Li+ halotolerance; activated by phosphatidylserine, cardiolipin and phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type 2"
Protein length	477
Download	sequence (fasta, from Uniprot), modifications (csv format)
Database links	Uniprot, SGD, TheCellVision.org, FungiDB

MYNRKDRDVH ERKEDGQSEF EALNGTNAIM SDNSKAYSIK FLTFNTWGLK
YVSKHRKERL RAIADKLAGH SMLTPISDEL LPNGGDSNEN EDYDVIALQE
IWCVEDWKYL ASACASKYPY QRLFHSGILT GPGLAILSKV PIESTFLYRF
PINGRPSAVF RGDWYVGKSI AITVLNTGTR PIAIMNSHMH APYAKQGDAA
YLCHRSCQAW DFSRLIKLYR QAGYAVIVVG DLNSRPGSLP HKFLTQEAGL
VDSWEQLHGK QDLAVIARLS PLQQLLKGCT TCDSLLNTWR AQRQPDEACR
LDYALIDPDF LQTVDAGVRF TERIPHLDCS VSDHFAYSCT LNIVPQGTES
RPSTSVKRAK THDRELILQR YSNYETMIEC IHTYLKTAQR QKFFRGLHFW
ASILLLIASL VVTTFTANKA GWSSIFWVLF AIAVSISGTI DGAISFLFGR
SEIRALIEVE QEVLDAEHHL QTFLSEK

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[117, Ubi]	Swaney, D.L.,  Beltrao, P.,  Starita, L.,  Guo, A.,  Rush, J.,  Fields, S.,  Krogan, N.J.,  Villén, J. (2013). Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nature Methods 10(7): 676-682. (Publication) (All modifications)
[270, Phos]	Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[270, Phos]	Vlastaridis P, Kyriakidou P, Chaliotis A, et al (2017) Estimating the total number of phosphoproteins and phosphorylation sites in eukaryotic proteomes. GigaScience 6:1–11. (Publication) (All modifications)
[270, Phos]	Bai Y, Chen B, Li M, et al (2017) FPD: A comprehensive phosphorylation database in fungi. Fungal Biology 121:869–875. (Publication) (All modifications)
[270, Phos]	Frankovsky, J., Vozáriková, V., Nosek, J., Tomáška, Ľ. (2021a). Mitochondrial protein phosphorylation in yeast revisited.Mitochondrion 57:148-162. (Publication) (All modifications)
[361, Phos]	Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB (2021). In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Reports, e51121. (Publication) (All modifications)
[361, Phos]	Schmitt, K.,  Smolinski, N.,  Neumann, P.,  Schmaul, S.,  Hofer-Pretz, V.,  Braus, G.H.,  Valerius, O. (2017). Asc1p/RACK1 connects ribosomes to eukaryotic phosphosignaling. Mol Cell Biol 37: e00279-16. (Publication) (All modifications)