Fang, N.N., Chan, G.T., Zhu, M., Comyn, S.A., Persaud, A., Deshaies, R.J., Rotin, D., Gsponer, J., Mayor, T. (2014). Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress. Nature Cell Biology 16(12): 1227-1237.
https://doi.org/10.1038/ncb3054
Heat stress induced PTMs (ubiqitylation, carbamoylation, Met oxidation)
| Uniprot ID | Systematic gene name | Standard gene name | Position | Modification type |
|---|---|---|---|---|
| P00330 | YOL086C | ADH1 | 8 | Ubiquitination |
| P00330 | YOL086C | ADH1 | 81 | Ubiquitination |
| P00330 | YOL086C | ADH1 | 207 | Ubiquitination |
| P00330 | YOL086C | ADH1 | 226 | Ubiquitination |
| P00331 | YMR303C | ADH2 | 84 | Ubiquitination |
| P00359 | YGR192C | TDH3 | 108 | Ubiquitination |
| P00549 | YAL038W | CDC19 | 86 | Ubiquitination |
| P00549 | YAL038W | CDC19 | 194 | Ubiquitination |
| P00560 | YCR012W | PGK1 | 258 | Ubiquitination |
| P00560 | YCR012W | PGK1 | 302 | Ubiquitination |
| P00924 | YGR254W | ENO1 | 85 | Ubiquitination |
| P00924 | YGR254W | ENO1 | 88 | Ubiquitination |
| P00950 | YKL152C | GPM1 | 133 | Ubiquitination |
| P02994 | YBR118W | TEF2 | 253 | Ubiquitination |
| P02994 | YBR118W | TEF2 | 271 | Ubiquitination |
| P02994 | YBR118W | TEF2 | 274 | Methionine oxidation |
| P04801 | YIL078W | THS1 | 85 | Ubiquitination |
| P04801 | YIL078W | THS1 | 702 | Methionine oxidation |
| P04801 | YIL078W | THS1 | 707 | Ubiquitination |
| P04817 | YEL063C | CAN1 | 5 | Ubiquitination |
| P04840 | YNL055C | POR1 | 61 | Ubiquitination |
| P05030 | YGL008C | PMA1 | 95 | Ubiquitination |
| P05030 | YGL008C | PMA1 | 417 | Ubiquitination |
| P05030 | YGL008C | PMA1 | 457 | Ubiquitination |
| P05030 | YGL008C | PMA1 | 644 | Ubiquitination |
| P05750 | YNL178W | RPS3 | 200 | Ubiquitination |
| P05750 | YNL178W | RPS3 | 212 | Ubiquitination |
| P07213 | YNL121C | TOM70 | 64 | Ubiquitination |
| P07213 | YNL121C | TOM70 | 87 | Ubiquitination |
| P07213 | YNL121C | TOM70 | 222 | Ubiquitination |
| P07213 | YNL121C | TOM70 | 300 | Ubiquitination |
| P07213 | YNL121C | TOM70 | 318 | Ubiquitination |
| P07213 | YNL121C | TOM70 | 533 | Ubiquitination |
| P07259 | YJL130C | URA2 | 1373 | Ubiquitination |
| P07259 | YJL130C | URA2 | 1990 | Ubiquitination |
| P08679 | YCR005C | CIT2 | 454 | Ubiquitination |
| P10592 | YLL024C | SSA2 | 556 | Ubiquitination |
| P10592 | YLL024C | SSA2 | 562 | Ubiquitination |
| P14540 | YKL060C | FBA1 | 55 | Ubiquitination |
| P14540 | YKL060C | FBA1 | 73 | Ubiquitination |
| P14540 | YKL060C | FBA1 | 199 | Ubiquitination |
| P14832 | YDR155C | CPR1 | 139 | Ubiquitination |
| P15454 | YDR454C | GUK1 | 15 | Ubiquitination |
| P16603 | YHR042W | NCP1 | 666 | Ubiquitination |
| P20081 | YNL135C | FPR1 | 10 | Ubiquitination |
| P22768 | YOL058W | ARG1 | 295 | Ubiquitination |
| P25605 | YCL009C | ILV6 | 284 | Ubiquitination |
| P25694 | YDL126C | CDC48 | 726 | Ubiquitination |
| P26783 | YJR123W | RPS5 | 87 | Carbamoylation |
| P29547 | YPL048W | CAM1 | 237 | Ubiquitination |
| P32598 | YER133W | GLC7 | 22 | Ubiquitination |
| P32628 | YEL037C | RAD23 | 13 | Ubiquitination |
| P32628 | YEL037C | RAD23 | 81 | Ubiquitination |
| P32798 | YOR316C | COT1 | 301 | Ubiquitination |
| P34760 | YML028W | TSA1 | 14 | Ubiquitination |
| P35691 | YKL056C | TMA19 | 97 | Ubiquitination |
| P36008 | YKL081W | TEF4 | 206 | Ubiquitination |
| P36008 | YKL081W | TEF4 | 210 | Ubiquitination |
| P36008 | YKL081W | TEF4 | 235 | Ubiquitination |
| P36008 | YKL081W | TEF4 | 236 | Ubiquitination |
| P36008 | YKL081W | TEF4 | 240 | Ubiquitination |
| P36008 | YKL081W | TEF4 | 409 | Ubiquitination |
| P36017 | YOR089C | VPS21 | 174 | Ubiquitination |
| P38013 | YLR109W | AHP1 | 113 | Ubiquitination |
| P38216 | YBR016W | YBR016W | 14 | Ubiquitination |
| P38219 | YBR025C | OLA1 | 162 | Ubiquitination |
| P38219 | YBR025C | OLA1 | 287 | Ubiquitination |
| P38219 | YBR025C | OLA1 | 365 | Ubiquitination |
| P38295 | YBR177C | EHT1 | 39 | Ubiquitination |
| P38297 | YBR179C | FZO1 | 398 | Ubiquitination |
| P38631 | YLR342W | FKS1 | 259 | Ubiquitination |
| P38631 | YLR342W | FKS1 | 413 | Ubiquitination |
| P38631 | YLR342W | FKS1 | 910 | Ubiquitination |
| P38631 | YLR342W | FKS1 | 1547 | Ubiquitination |
| P38701 | YHL015W | RPS20 | 6 | Ubiquitination |
| P38701 | YHL015W | RPS20 | 8 | Ubiquitination |
| P39935 | YGR162W | TIF4631 | 689 | Ubiquitination |
| P39935 | YGR162W | TIF4631 | 906 | Ubiquitination |
| P40825 | YOR335C | ALA1 | 646 | Ubiquitination |
| P43582 | YFL010C | WWM1 | 60 | Ubiquitination |
| P43585 | YFL004W | VTC2 | 676 | Ubiquitination |
| P46655 | YGL245W | GUS1 | 47 | Ubiquitination |
| P46655 | YGL245W | GUS1 | 198 | Ubiquitination |
| P46655 | YGL245W | GUS1 | 632 | Ubiquitination |
| P46672 | YGL105W | ARC1 | 147 | Ubiquitination |
| P48813 | YDR508C | GNP1 | 41 | Ubiquitination |
| P48813 | YDR508C | GNP1 | 122 | Ubiquitination |
| P53112 | YGL153W | PEX14 | 7 | Ubiquitination |
| P53297 | YGR178C | PBP1 | 445 | Ubiquitination |
| Q00955 | YNR016C | ACC1 | 710 | Ubiquitination |
| Q00955 | YNR016C | ACC1 | 857 | Ubiquitination |
| Q00955 | YNR016C | ACC1 | 898 | Ubiquitination |
| Q04697 | YML048W | GSF2 | 228 | Ubiquitination |
| Q05506 | YDR341C | YDR341C | 412 | Ubiquitination |
| Q08245 | YOL109W | ZEO1 | 7 | Ubiquitination |
| Q08245 | YOL109W | ZEO1 | 23 | Ubiquitination |
| Q08245 | YOL109W | ZEO1 | 45 | Ubiquitination |
| Q08245 | YOL109W | ZEO1 | 69 | Ubiquitination |
| Q08972 | YPL226W | NEW1 | 322 | Ubiquitination |
| Q08972 | YPL226W | NEW1 | 1138 | Ubiquitination |
| Q12230 | YPL004C | LSP1 | 29 | Ubiquitination |
| Q12680 | YDL171C | GLT1 | 868 | Ubiquitination |
| Q12680 | YDL171C | GLT1 | 1299 | Ubiquitination |
| Q12680 | YDL171C | GLT1 | 1617 | Ubiquitination |
| Q12680 | YDL171C | GLT1 | 1629 | Ubiquitination |
| Q12691 | YDR038C | ENA5 | 588 | Carbamoylation |